In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve

被引:466
作者
Nassif, NA
Cense, B
Park, BH
Pierce, MC
Yun, SH
Bouma, BE
Tearney, GJ
Chen, TC
de Boer, JF
机构
[1] Harvard Univ, Sch Med, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
[3] Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA
来源
OPTICS EXPRESS | 2004年 / 12卷 / 03期
关键词
D O I
10.1364/OPEX.12.000367
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
An ultra-high- speed spectral-domain optical coherence tomography system (SD-OCT) was developed for imaging the human retina and optic nerve in vivo at a sustained depth profile (A-line) acquisition speed of 29 kHz. The axial resolution was 6 mum in tissue and the system had shot-noise-limited performance with a maximum sensitivity of 98.4 dB. 3-dimensional data sets were collected in 11 and 13 seconds for the macula and optic nerve head respectively and are presented to demonstrate the potential clinical applications of SD-OCT in ophthalmology. Additionally, a 3-D volume of the optic nerve head was constructed from the acquired data and the retinal vascular network was visualized.
引用
收藏
页码:367 / 376
页数:10
相关论文
共 19 条
[1]  
[Anonymous], 2007, Z13612000 ANSI LAS I
[2]   OPTICAL AND RETINAL FACTORS AFFECTING VISUAL RESOLUTION [J].
CAMPBELL, FW ;
GREEN, DG .
JOURNAL OF PHYSIOLOGY-LONDON, 1965, 181 (03) :576-+
[3]   In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography [J].
Cense, B ;
Chen, TC ;
Park, BH ;
Pierce, MC ;
de Boer, JF .
OPTICS LETTERS, 2002, 27 (18) :1610-1612
[4]   Sensitivity advantage of swept source and Fourier domain optical coherence tomography [J].
Choma, MA ;
Sarunic, MV ;
Yang, CH ;
Izatt, JA .
OPTICS EXPRESS, 2003, 11 (18) :2183-2189
[5]   Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography [J].
de Boer, JF ;
Cense, B ;
Park, BH ;
Pierce, MC ;
Tearney, GJ ;
Bouma, BE .
OPTICS LETTERS, 2003, 28 (21) :2067-2069
[6]   Spectral resolution and sampling issues in Fourier-transform spectral interferometry [J].
Dorrer, C ;
Belabas, N ;
Likforman, JP ;
Joffre, M .
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS, 2000, 17 (10) :1795-1802
[7]   Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography [J].
Drexler, W ;
Sattmarin, H ;
Hermann, B ;
Ko, TH ;
Stur, M ;
Unterhuber, A ;
Scholda, C ;
Findl, O ;
Wirtitsch, M ;
Fujimoto, JG ;
Fercher, AF .
ARCHIVES OF OPHTHALMOLOGY, 2003, 121 (05) :695-706
[8]   MEASUREMENT OF INTRAOCULAR DISTANCES BY BACKSCATTERING SPECTRAL INTERFEROMETRY [J].
FERCHER, AF ;
HITZENBERGER, CK ;
KAMP, G ;
ELZAIAT, SY .
OPTICS COMMUNICATIONS, 1995, 117 (1-2) :43-48
[9]  
Fercher AF, 2003, REP PROG PHYS, V66, P239, DOI [10.1088/0034-4885/66/2/204, 10.2184/lsj.31.635]
[10]  
Häusler G, 1998, J BIOMED OPT, V3, P21, DOI 10.1117/1.429899