Mental retardation in Down syndrome: a hydrogen sulfide hpothesis

被引：67

作者：

Kamoun, P ^{[1
]}

机构：

[1] Hop Necker Enfants Malad, CNRS, Lab Biochem Med B, UMR 8602, F-75743 Paris 15, France

来源：

MEDICAL HYPOTHESES | 2001年 / 57卷 / 03期

关键词：

D O I：

10.1054/mehy.2001.1377

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Mental retardation is progressive in Down syndrome: individuals are born with normal intelligence which starts to decline linearly within the first year. This phenomenon can be observed with phenylalanine in patients with phenylketonuria, therefore it is compatible with metabolic intoxication. The toxic compound could be hydrogen sulfide. The amount of the compound is probably increased in Down syndrome by increasing active cystathionine beta synthase. This heuristic hypothesis requires further investigation. (C) 2001 Harcourt Publishers Ltd.

引用

页码：389 / 392

页数：4

共 33 条

[1]

Abe K, 1996, J NEUROSCI, V16, P1066

[2] TURNOVER OF BRAIN MONOAMINE-OXIDASE MEASURED INVIVO BY POSITRON EMISSION TOMOGRAPHY USING L-[C-11]DEPRENYL [J].

ARNETT, CD ;

FOWLER, JS ;

MACGREGOR, RR ;

SCHLYER, DJ ;

WOLF, AP ;

LANGSTROM, B ;

HALLDIN, C .

JOURNAL OF NEUROCHEMISTRY, 1987, 49 (02) :522-527

[3] Cerebellar volume in adults with Down syndrome [J].

Aylward, EH ;

Habbak, R ;

Warren, AC ;

Pulsifer, MB ;

Barta, PE ;

Jerram, M ;

Pearlson, GD .

ARCHIVES OF NEUROLOGY, 1997, 54 (02) :209-212

[4] EFFECTS OF MERCAPTANS UPON DIHYDROPYRIDINE BINDING-SITES ON TRANSVERSE TUBULES ISOLATED FROM TRIADS OF RABBIT SKELETAL-MUSCLE [J].

BRANDT, NR ;

KAWAMOTO, RM ;

CASWELL, AH .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 127 (01) :205-212

[5]

CHADEFAUX B, 1988, LANCET, V2, P741

[6] CYSTATHIONINE BETA SYNTHASE - GENE DOSAGE EFFECT IN TRISOMY-21 [J].

CHADEFAUX, B ;

RETHORE, MO ;

RAOUL, O ;

CEBALLOS, I ;

POISSONNIER, M ;

GILGENKRANZ, S ;

ALLARD, D .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 128 (01) :40-44

[7] DETOXICATION OF SODIUM S-35-SULFIDE IN RAT [J].

CURTIS, CG ;

DODGSON, KS ;

ROSE, FA ;

BARTHOLOMEW, TC .

BIOCHEMICAL PHARMACOLOGY, 1972, 21 (17) :2313-+

[8]

DOBSON JC, 1978, PEDIATRICS, V58, P53

[9] CHRONIC EXPOSURE TO LOW CONCENTRATIONS OF HYDROGEN-SULFIDE PRODUCES ABNORMAL GROWTH IN DEVELOPING CEREBELLAR PURKINJE-CELLS [J].

HANNAH, RS ;

ROTH, SH .

NEUROSCIENCE LETTERS, 1991, 122 (02) :225-228

[10] The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide [J].

Hosoki, R ;

Matsuki, N ;

Kimura, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 237 (03) :527-531

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