Early events in the DNA damage response

被引：35

作者：

Ward, I ^{[1
]}

Chen, JJ ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Div Oncol Res, Rochester, MN 55905 USA

来源：

CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 63 | 2004年 / 63卷

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0070-2153(04)63001-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The ability to sense DNA damage and activate response pathways that coordinate cell cycle progression and DNA repair is essential for the maintenance of genomic integrity and the viability of organisms. During the last couple of years, several proteins have been identified that participate very early in the DNA damage response. Here we review the current understanding of the mechanisms by which mammalian cells detect DNA lesions, especially double-strand breaks, and mediate the signal to downstream transducers. © 2004 Elsevier Inc. All rights reserved.

引用

页码：1 / 35

页数：35

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