Natural killer cells and hepatitis C: action and reaction

被引：74

作者：

Cheent, Kuldeep ^{[1
]}

Khakoo, Salim I. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Div Med, London W2 1NS, England

来源：

GUT | 2011年 / 60卷 / 02期

基金：

英国惠康基金;

关键词：

B-VIRUS INFECTION; HUMAN NK CELLS; INHIBITORY RECEPTOR GENES; ADAPTIVE IMMUNE-RESPONSES; I-RELATED CHAIN; COMPLEX CLASS-I; HEPATOCELLULAR-CARCINOMA; INTERFERON-ALPHA; HLA-C; LIVER-TRANSPLANTATION;

D O I：

10.1136/gut.2010.212555

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In 1989, hepatitis C virus (HCV) was first identified as the infectious agent responsible for human non-A, non-B hepatitis.(1) Two decades later, HCV remains a global public health problem with a suboptimal response rate to treatment and the absence of a protective vaccine. Recent work has highlighted the influence of the innate immune system, and in particular natural killer cells, on the outcome and pathology of HCV infection. These cells are considerably more complex than was originally thought and their role in viral infections is currently being unravelled. This review summarises our emerging understanding of natural killer cells in HCV infection.

引用

页码：268 / 278

页数：11

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