Polymer-bound 4-benzylsulfonyl-1-triphenylphosphoranylidene-2-butanone as a tool for the solid-phase synthesis of substituted piperidin-4-one derivatives.

被引：28

作者：

Barco, A

Benetti, S

De Risi, C

Marchetti, P

Pollini, GP

Zanirato, V

机构：

[1] Univ Ferrara, Dipartmento Chim, I-44100 Ferrara, Italy

[2] Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 41期

关键词：

solid-phase synthesis; Michael reactions; piperidinones;

D O I：

10.1016/S0040-4039(98)01650-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the construction of 2-substituted-piperidin-4-one derivatives on solid support has been developed using polymer-bound 4-benzylsulfonyl-I-triphenylphosphoranylidene-2-butanone as a convenient precursor for substituted divinyl ketones in the heterocyclization reaction with amines. The resin was released in a recyclable sulfinate form. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7591 / 7594

页数：4

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