Relationship of genotypes of hepatitis B virus to mutations, disease progression and response to antiviral therapy

被引：151

作者：

Kramvis, A ^{[1
]}

Kew, MC ^{[1
]}

机构：

[1] Univ Witwatersrand, Sch Med, Dept Med, MRC,Univ Mol Hepatol Res Unit, ZA-2193 Johannesburg, South Africa

来源：

JOURNAL OF VIRAL HEPATITIS | 2005年 / 12卷 / 05期

关键词：

disease progression; genotypes; hepatitis B virus; mutants; therapy;

D O I：

10.1111/j.1365-2893.2005.00624.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Phylogenetic analysis has led to the classification of hepatitis B virus into eight genotypes, designated A to H. The genotypes have differences in biological properties and show heterogeneity in their global distribution. These attributes of the genotypes may account not only for differences in the prevalence of hepatitis B virus mutants in various geographic regions, but also be responsible for differences in the clinical outcome and response to antiviral treatment in different population groups.

引用

页码：456 / 464

页数：9

共 133 条

[1] Interferon-alpha 2a for chronic hepatitis B with e antigen or antibody: Comparable antiviral effects on wild-type virus and precore mutant [J].