Central injection in rats of α-melanocyte-stimulating hormone analog:: effects on food intake and brain Fos

被引:73
作者
Brown, KS [1 ]
Gentry, RM [1 ]
Rowland, NE [1 ]
机构
[1] Univ Florida, Dept Psychol, Gainesville, FL 32611 USA
关键词
lateral and fourth cerebral ventricles; neuropeptide Y; paraventricular nucleus; arcuate nucleus; striatum; fos-immunocytochemistry;
D O I
10.1016/S0167-0115(98)00127-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Lateral cerebroventricular (LCVT) administration of the alpha-MSH agonist analog Nle(4)DPhe(7)alpha-MSH (NDP-MSH) inhibited food intake in food-deprived rats, but did not inhibit water intake in water-deprived rats. When NDP-MSH was administered into the fourth ventricle (4CVT), comparable suppressions of food intake were observed. LCVT and 4CVT administration of NDP-MSH also reduced spontaneous 24 h food intake. LCVT injection of NDP-MSH greatly attenuated food intake stimulated in sated rats by acute CVT administration of neuropeptide Y (NPY). These and other data suggest that alpha-MSH is an important endogenous regulator of food intake, possibly acting downstream of NPY. In an attempt to assess further the sites of action of NDP-MSH, a qualitative mapping study of Fos-like immunoreactive (Fos-ir) neurons was performed following LCVT administration of NDP-MSH. LCVT injection of NDP-MSH induced Fos-ir in several forebrain regions including cortex, striatum, bed nucleus of the stria terminalis, paraventricular nucleus of the hypothalamus and arcuate nucleus. The combination of NPY and NDP-MSH did not produce obvious antagonism or cancellation of effects in any region examined. Thus, the site(s) of action of NDP-MSH on food intake remain to be clarified. (C) 1998 Elsevier Science B.V. All rights reserved.
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页码:89 / 94
页数:6
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