Coxsackievirus and adenovirus receptor cytoplasmic and transmembrane domains are not essential for coxsackievirus and adenovirus infection

被引：133

作者：

Wang, XH ^{[1
]}

Bergelson, JM ^{[1
]}

机构：

[1] Childrens Hosp Philadelphia, Div Immunol & Infect Dis, Philadelphia, PA 19104 USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 03期

关键词：

D O I：

10.1128/JVI.73.3.2559-2562.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Coxsackievirus and adenovirus receptor (CAR) from which the cytoplasmic domain had been deleted and glycosylphosphatidylinositol (GPI)-anchored CAR lacking both transmembrane and cytoplasmic domains were both capable of facilitating adenovirus 5-mediated gene delivery and infection by coxsackievirus B3. These results indicate that the CAR extracellular domain is sufficient to permit virus attachment and entry and that the presence of a GPI anchor does not prevent infection.

引用

页码：2559 / 2562

页数：4

共 34 条

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