Caveolae as portals of entry for microbes

被引：105

作者：

Shin, JS

Abraham, SN ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Microbiol, Durham, NC 27710 USA

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 09期

关键词：

caveolae; lipid raft; endocytosis; microbes; toxin;

D O I：

10.1016/S1286-4579(01)01423-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Many pathogens, including many traditionally extracellular microbes, now appear capable of entry into host cells with limited loss of viability. A portal of entry shared by some bacteria, bacterial toxins, viruses and parasites are caveolae (or lipid rafts), which are involved in the import and intracellular translocation of macromolecules in host cells. A requirement for caveolae-mediated endocytosis of microbes appears to be that the respective receptor is a constituent of caveolae or must move to caveolae following ligation. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

收藏

页码：755 / 761

页数：7

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