Deconstructing type 2 diabetes

被引:247
作者
Taylor, SI [1 ]
机构
[1] NIDDKD, Diabet Branch, Div Intramural Res, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1016/S0092-8674(00)80709-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:9 / 12
页数:4
相关论文
共 26 条
[1]   Early neonatal death in mice homozygous for a null allele of the insulin receptor gene [J].
Accili, D ;
Drago, J ;
Lee, EJ ;
Johnson, MD ;
Cool, MH ;
Salvatore, P ;
Asico, LD ;
Jose, PA ;
Taylor, SI ;
Westphal, H .
NATURE GENETICS, 1996, 12 (01) :106-109
[2]   A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling - Evidence from transfection studies [J].
Almind, K ;
Inoue, G ;
Pedersen, O ;
Kahn, CR .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (11) :2569-2575
[3]   Insulin-stimulated insulin secretion in single pancreatic beta cells [J].
Aspinwall, CA ;
Lakey, JRT ;
Kennedy, RT .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (10) :6360-6365
[4]   Glucokinase mutations, insulin secretion, and diabetes mellitus [J].
Bell, GI ;
Pilkis, SJ ;
Weber, IT ;
Polonsky, KS .
ANNUAL REVIEW OF PHYSIOLOGY, 1996, 58 :171-+
[5]  
Bergami G, 1997, BELFAGOR, V52, P359
[6]   A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance [J].
Bruning, JC ;
Michael, MD ;
Winnay, JN ;
Hayashi, T ;
Horsch, D ;
Accili, D ;
Goodyear, LJ ;
Kahn, CR .
MOLECULAR CELL, 1998, 2 (05) :559-569
[7]   Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles [J].
Bruning, JC ;
Winnay, J ;
BonnerWeir, S ;
Taylor, SI ;
Accili, D ;
Kahn, CR .
CELL, 1997, 88 (04) :561-572
[8]  
DeFronzo RA, 1997, DIABETES REV, V5, P177
[9]  
ELDERS MJ, 1982, J NATL MED ASSOC, V74, P1195
[10]   Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY [J].
Horikawa, Y ;
Iwasaki, N ;
Hara, M ;
Furuta, H ;
Hinokio, Y ;
Cockburn, BN ;
Lindner, T ;
Yamagata, K ;
Ogata, M ;
Tomonaga, O ;
Kuroki, H ;
Kasahara, T ;
Iwamoto, Y ;
Bell, GI .
NATURE GENETICS, 1997, 17 (04) :384-385