Peptide based inhibitors of interleukin-8: Structural simplification and enhanced potency

被引：19

作者：

Attwood, MR

Conway, EA

Dunsdon, RM

Greening, JR

Handa, BK

Jones, PS

Jordan, SC

Keech, E

Wilson, FX

机构：

[1] ROCHE PROD LTD,DEPT MED CHEM,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND

[2] ROCHE PROD LTD,DEPT PHYS METHODS,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(97)00036-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Important areas of a lead peptide inhibitor of IL-I had been previously identified. Chemical modification led to the identification of key amide bonds which allowed the replacement of the central section of the peptide with modified amino acids and spacers. This approach led to inhibitors of lower molecular weight and of increased potency. (C) 1997, Elsevier Science Ltd.

引用

页码：429 / 432

页数：4

共 9 条

[1] BOLIN DR, 1989, INT J PEPT PROT RES, V33, P353
[2] ASYMMETRIC-SYNTHESIS OF R-BETA-AMINO BUTANOIC ACID AND S-BETA-TYROSINE - HOMOCHIRAL LITHIUM AMIDE EQUIVALENTS FOR MICHAEL ADDITIONS TO ALPHA,BETA-UNSATURATED ESTERS
DAVIES, SG
ICHIHARA, O
[J]. TETRAHEDRON-ASYMMETRY, 1991, 2 (03) : 183 - 186
[3] EVANS DA, 1991, J ORG CHEM, V56, P5720
[4] JONES PS, 1996, BIORG MED CHEM LETT, V6, P1869
[5] KOCH AE, 1991, J IMMUNOL, V147, P2187
[6] MULLIGAN MS, 1993, J IMMUNOL, V150, P5585
[7] PROPERTIES OF THE NOVEL PROINFLAMMATORY SUPERGENE INTERCRINE CYTOKINE FAMILY
OPPENHEIM, JJ
ZACHARIAE, COC
MUKAIDA, N
MATSUSHIMA, K
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1991, 9 : 617 - 648
[8] A GENERAL-ROUTE TO CARBA-PEPTIDE BOND REPLACEMENTS - UNEQUIVOCAL SYNTHESIS OF BOC-L-PHE-PSI(CH2-CH2)-L-ALA-OH AND BOC-L-PHE-PSI(CH2-CH2)-D-ALA-OH
RODRIGUEZ, M
AUMELAS, A
MARTINEZ, J
[J]. TETRAHEDRON LETTERS, 1990, 31 (36) : 5153 - 5156
[9] SEKIDO N, 1993, NATURE, V365, P554

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