Leukaemia stem cells and the evolution of cancer-stem-cell research

被引：464

作者：

Huntly, BJP ^{[1
]}

Gilliland, DG

机构：

[1] Brigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 04期

关键词：

D O I：

10.1038/nrc1592

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many cancers seem to depend on a small population of 'cancer stem cells' for their continued growth and propagation. The leukaemia stem cell (LSC) was the first such cell to be described. The origins of these cells are controversial, and their biology-like that of their normal-tissue counterpart, the haematopoietic stem cell (HSC)-is still not fully elucidated. However, the LSC is likely to be the most crucial target in the treatment of leukaemias, and a thorough understanding of its biology-particularly of how the LSC differs from the HSC-might allow it to be selectively targeted, improving therapeutic outcome.

引用

页码：311 / 321

页数：11

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