Effects of structural modification of calcium spirulan, a sulfated polysaccharide from Spirulina platensis, on antiviral activity

被引：47

作者：

Lee, JB

Srisomporn, P

Hayashi, K

Tanaka, T

Sankawa, U

Hayashi, T

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Toyama 9300194, Japan

[2] Toyama Med & Pharmaceut Univ, Sch Med, Toyama 9300194, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 01期

关键词：

calcium spirulan; sulfated polysaccharide; antiviral activity; HSV-1; metal cation; depolymerization;

D O I：

10.1248/cpb.49.108

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Calcium ion binding with the anionic part of a molecule was replaced with various metal cations and their inhibitory effects on the replication of herpes simplex virus type 1 were evaluated. Replacement of calcium ion,vith sodium and potassium ions maintained the antiviral activity while divalent and trivalent metal cations reduced the activity, Depolymerization of sodium spirulan with hydrogen peroxide decreased in antiviral activity as its molecular weight decreased.

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收藏

页码：108 / 110

页数：3

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