Nerve Growth Factor: A Focus on Neuroscience and Therapy

被引：221

作者：

Aloe, Luigi ^{[1
]}

Rocco, Maria Luisa ^{[1
]}

Balzamino, Bijorn Omar ^{[2
]}

Micera, Alessandra ^{[2
]}

机构：

[1] CNR, Inst Cell Biol & Neurobiol, I-00143 Rome, Italy

[2] IRCCS GB Bietti Fdn, Rome, Italy

来源：

CURRENT NEUROPHARMACOLOGY | 2015年 / 13卷 / 03期

关键词：

Clinical trials; NGF; NGF-healing action; treatment; NGF receptors; visual system; FACTOR EYE DROPS; CHOLINERGIC NEURON ATROPHY; RANDOMIZED CLINICAL-TRIAL; RETINAL GANGLION-CELLS; ADULT SENSORY NEURONS; RETINITIS-PIGMENTOSA; NEUROTROPHIC FACTORS; TOPICAL APPLICATION; OPTIC-NERVE; FACTOR NGF;

D O I：

10.2174/1570159X13666150403231920

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Nerve growth factor (NGF) is the firstly discovered and best characterized neurotrophic factor, known to play a critical protective role in the development and survival of sympathetic, sensory and forebrain cholinergic neurons. NGF promotes neuritis outgrowth both in vivo and in vitro and nerve cell recovery after ischemic, surgical or chemical injuries. Recently, the therapeutic property of NGF has been demonstrated on human cutaneous and corneal ulcers, pressure ulcer, glaucoma, maculopathy and retinitis pigmentosa. NGF eye drops administration is well tolerated, with no detectable clinical evidence of systemic or local adverse effects. The aim of this review is to summarize these biological properties and the potential clinical development of NGF.

引用

页码：294 / 303

页数：10

共 96 条

[1]

Protective role of nerve growth factor against postischemic dysfunction of sympathetic coronary innervation [J].