Consensus recommendations for standard investigative workup: report of the International Myeloma Workshop Consensus Panel 3

被引：328

作者：

Dimopoulos, Meletios ^{[1
]}

Kyle, Robert ^{[2
]}

Fermand, Jean-Paul ^{[3
]}

Rajkumar, S. Vincent ^{[2
]}

San Miguel, Jesus ^{[4
]}

Chanan-Khan, Asher ^{[5
]}

Ludwig, Heinz ^{[6
]}

Joshua, Douglas ^{[7
]}

Mehta, Jayesh ^{[8
]}

Gertz, Morie ^{[2
]}

Avet-Loiseau, Herve ^{[9
]}

Beksac, Meral ^{[10
]}

Anderson, Kenneth C. ^{[11
]}

Moreau, Philippe ^{[9
]}

Singhal, Seema ^{[8
]}

Goldschmidt, Hartmut ^{[12
]}

Boccadoro, Mario ^{[13
]}

Kumar, Shaji ^{[2
]}

Giralt, Sergio ^{[14
]}

Munshi, Nikhil C. ^{[15
]}

Jagannath, Sundar ^{[16
]}

机构：

[1] Univ Athens, Athens 14561, Greece

[2] Mayo Clin, Rochester, MN USA

[3] Hop St Louis, Paris, France

[4] Univ Salamanca, E-37008 Salamanca, Spain

[5] Roswell Pk Canc Ctr, Buffalo, NY USA

[6] Wilhelminen Hosp, Vienna, Austria

[7] Bosch Inst, Camperdown, NSW, Australia

[8] Robert H Lurie Comprehens Canc Ctr, Chicago, IL USA

[9] Univ Nantes, Nantes, France

[10] Ankara Univ, Ibn Sina Hosp, TR-06100 Ankara, Turkey

[11] Dana Farber Canc Inst, Boston, MA 02115 USA

[12] Heidelberg Univ, Heidelberg, Germany

[13] Univ Turin, Turin, Italy

[14] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[15] Boston Vet Adm Healthcare Syst, W Roxbury, MA USA

[16] Mt Sinai Med Ctr, New York, NY 10029 USA

来源：

BLOOD | 2011年 / 117卷 / 18期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; INDEPENDENT RISK-FACTOR; LIGHT-CHAIN RATIO; MULTIPLE-MYELOMA; PROGNOSTIC-SIGNIFICANCE; SOLITARY PLASMACYTOMA; SERUM-ALBUMIN; BONE-MARROW; IMMUNOGLOBULIN; DIAGNOSIS;

D O I：

10.1182/blood-2010-10-299529

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

A panel of members of the 2009 International Myeloma Workshop developed guidelines for standard investigative workup of patients with suspected multiple myeloma. Both serum and urine should be assessed for monoclonal protein. Measurement of monoclonal protein both by densitometer tracing and/by nephelometric quantitation is recommended, and immunofixation is required for confirmation. The serum-free light chain assay is recommended in all newly diagnosed patients with plasma cell dyscrasias. Bone marrow aspiration and/or biopsy along with demonstration of clonality of plasma cells are necessary. Serum beta 2-microglobulin, albumin, and lactate dehydrogenase are necessary for prognostic purposes. Standard metaphase cytogenetics and fluorescent in situ hybridization for 17p, t(4; 14), and t(14; 16) are recommended. The skeletal survey remains the standard method for imaging screening, but magnetic resonance imaging frequently provides valuable diagnostic and prognostic information. Most of these tests are repeated during follow-up or at relapse. (Blood. 2011; 117(18): 4701-4705)

引用

页码：4701 / 4705

页数：5

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