Natural products as a source of Alzheimer's drug leads

被引：348

作者：

Williams, Philip ^{[1
,2
]}

Sorribas, Analia ^{[1
,2
]}

Howes, Melanie-Jayne R. ^{[3
]}

机构：

[1] Univ Hawaii Manoa, Dept Chem, Honolulu, HI 96822 USA

[2] Canc Res Ctr Hawaii, Honolulu, HI 96813 USA

[3] Royal Bot Gardens, Jodrell Lab, Richmond TW9 3AB, Surrey, England

来源：

NATURAL PRODUCT REPORTS | 2011年 / 28卷 / 01期

关键词：

PROTEIN-KINASE-C; BETA-AMYLOID FIBRILS; ACETYLCHOLINESTERASE-INHIBITORY-ACTIVITY; SECRETASE BACE1 INHIBITORS; LAVANDULAEFOLIA ESSENTIAL OIL; DISEASE-MODIFYING THERAPIES; GLYCOGEN-SYNTHASE KINASE-3; INDUCED MEMORY IMPAIRMENT; ALPHA-CONVERTING-ENZYME; PEROXIDE-INDUCED INJURY;

D O I：

10.1039/c0np00027b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

This review focuses on recent developments in the use of natural products as therapeutics for Alzheimer's disease. The compounds span a diverse array of structural classes and are organized according to their mechanism of action, with the focus primarily on the major hypotheses. Overall, the review discusses more than 180 compounds and summarizes 400 references.

引用

页码：48 / 77

页数：30

共 400 条

[1]

Aggarwal BB, 2003, ANTICANCER RES, V23, P363

[2]

Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat [J].