Nanoparticle Biokinetics in Mice and Nonhuman Primates

被引:34
作者
Chiarelli, Peter A. [1 ]
Revia, Richard A. [2 ]
Stephen, Zachary R. [2 ]
Wang, Kui [2 ]
Jeon, Mike [2 ]
Nelson, Veronica [6 ]
Kievit, Forrest M. [1 ,2 ]
Sham, Jonathan [3 ]
Ellenbogen, Richard G. [1 ,4 ]
Kiem, Hans-Peter [5 ,6 ]
Zhang, Miqin [1 ,2 ,4 ]
机构
[1] Univ Washington, Dept Neurol Surg, Seattle, WA 98195 USA
[2] Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA
[3] Univ Washington, Dept Surg, Seattle, WA 98195 USA
[4] Univ Washington, Dept Radiol, Seattle, WA 98195 USA
[5] Univ Washington, Dept Med & Pathol, Seattle, WA 98195 USA
[6] Fred Hutchinson Canc Res Ctr, Clin Res Div, Seattle, WA 98109 USA
关键词
iron oxide nanoparticle; biokinetics; cross-species; magnetic resonance imaging; nonhuman primates; mice; IRON-OXIDE NANOPARTICLES; STATIC DEPHASING REGIME; BLOOD-BRAIN-BARRIER; IN-VIVO; MAGNETIC NANOPARTICLES; BIOLOGICAL BARRIERS; SPECIES-DIFFERENCES; CANCER-DIAGNOSIS; BIODISTRIBUTION; CLEARANCE;
D O I
10.1021/acsnano.7b05377
中图分类号
O6 [化学];
学科分类号
070301 [无机化学];
摘要
Despite the preponderance of iron oxide nanopartides (NPs) designed for theranostic applications, widespread clinical translation of these NPs lags behind. A better understanding of how NP pharmacokinetics vary between small and large animal models is needed to rapidly customize NPs for optimal performance in humans. Here we use non-invasive magnetic resonance imaging (MRI) to track iron oxide NPs through a large number of organ systems in vivo to investigate NP biokinetics in both mice and nonhuman primates. We demonstrate that pharmacokinetics are similar between mice and macaques in the blood, liver, spleen, and muscle, but differ in the kidneys, brain, and bone marrow. Our study also demonstrates that full-body MRI is practical, rapid, and cost-effective for tracking NPs noninvasively with high spatiotemporal resolution. Our techniques using a nonhuman primate model may provide a platform for testing a range of NP formulations.
引用
收藏
页码:9514 / 9524
页数:11
相关论文
共 52 条
[1]
Longitudinal 3He and proton imaging of magnetite biodistribution in a rat model of instilled nanoparticles [J].
Al Faraj, Achraf ;
Lacroix, Ghislaine ;
Alsaid, Hasan ;
Elgrabi, Dan ;
Stupar, Vasile ;
Robidel, Franck ;
Gaillard, Sophie ;
Canet-Soulas, Ernmanuelle ;
Cremillieux, Yannick .
MAGNETIC RESONANCE IN MEDICINE, 2008, 59 (06) :1298-1303
[2]
In Vivo Imaging of Carbon Nanotube Biodistribution Using Magnetic Resonance Imaging [J].
Al Faraj, Achraf ;
Cieslar, Katarzyna ;
Lacroix, Ghislaine ;
Gaillard, Sophie ;
Canot-Soulas, Emmanuelle ;
Cremillieux, Yannick .
NANO LETTERS, 2009, 9 (03) :1023-1027
[3]
In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles [J].
Arami, Hamed ;
Khandhar, Amit ;
Liggitt, Denny ;
Krishnan, Kannan M. .
CHEMICAL SOCIETY REVIEWS, 2015, 44 (23) :8576-8607
[4]
Nanotoxicology and in vitro studies: The need of the hour [J].
Arora, Sumit ;
Rajwade, Jyutika M. ;
Paknikar, Kishore M. .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2012, 258 (02) :151-165
[5]
Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat [J].
Barrefelt, Asa ;
Saghafian, Maryam ;
Kuiper, Raoul ;
Ye, Fei ;
Egri, Gabriella ;
Klickermann, Moritz ;
Brismar, Torkel B. ;
Aspelin, Peter ;
Muhammed, Mamoun ;
Daehne, Lars ;
Hassan, Moustapha .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2013, 8 :3241-3254
[6]
Application of the static dephasing regime theory to superparamagnetic iron-oxide loaded cells [J].
Bowen, CV ;
Zhang, XW ;
Saab, G ;
Gareau, PJ ;
Rutt, BK .
MAGNETIC RESONANCE IN MEDICINE, 2002, 48 (01) :52-61
[7]
Renal clearance of quantum dots [J].
Choi, Hak Soo ;
Liu, Wenhao ;
Misra, Preeti ;
Tanaka, Eiichi ;
Zimmer, John P. ;
Ipe, Binil Itty ;
Bawendi, Moungi G. ;
Frangioni, John V. .
NATURE BIOTECHNOLOGY, 2007, 25 (10) :1165-1170
[8]
Recent advances in iron oxide nanocrystal technology for medical imaging [J].
Corot, Claire ;
Robert, Philippe ;
Idee, Jean-Marc ;
Port, Marc .
ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (14) :1471-1504
[9]
ICP-MS analysis of lanthanide-doped nanoparticles as a non-radiative, multiplex approach to quantify biodistribution and blood clearance [J].
Crayton, Samuel H. ;
Elias, Drew R. ;
Al Zaki, Ajlan ;
Cheng, Zhiliang ;
Tsourkas, Andrew .
BIOMATERIALS, 2012, 33 (05) :1509-1519
[10]
Current Limitations of Molecular Magnetic Resonance Imaging for Tumors as Evaluated With High-Relaxivity CD105-Specific Iron Oxide Nanoparticles [J].
Dassler, Katrin ;
Roohi, Farnoosh ;
Lohrke, Jessica ;
Ide, Andreas ;
Remmele, Stefanie ;
Huetter, Joachim ;
Pietsch, Hubertus ;
Pison, Ulrich ;
Schuetz, Gunnar .
INVESTIGATIVE RADIOLOGY, 2012, 47 (07) :383-391