An improved protocol for azole synthesis with PEG-supported burgess reagent

被引：106

作者：

Wipf, P

Venkatraman, S

机构：

[1] Department of Chemistry, University of Pittsburgh, Pittsburgh

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 27期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(96)00918-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A polyethyleneglycol-linked version of Burgess reagent was developed and applied toward the cyclodehydration of beta-hydroxy amides and thioamides. The desired oxazolines and thiazolines were obtained in high yields and excellent purities. The major advantages of the polymer bound reagent are its improved ease of handling and greatly increased yields in the synthesis of labile oxazolines. Copyright (C) 1996 Elsevier Science Ltd

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页码：4659 / 4662

页数：4

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