Propofol: An immunomodulating agent

被引：101

作者：

Marik, PE ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Div Pulm & Crit Care Med, Philadelphia, PA 19107 USA

来源：

PHARMACOTHERAPY | 2005年 / 25卷 / 05期

关键词：

propofol; ethylenediaminetetraacetic acid; metabisulfite; EDTA; cytokines; nuclear factor-kappa B; nitric oxide; lipid peroxidation; antioxidant;

D O I：

10.1592/phco.2005.25.5_Part_2.28S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Propofol (2,6-diisopropylphenol) is a potent intravenous hypnotic agent widely administered for induction and maintenance of anesthesia and for sedation in the intensive care unit. Propofol is insoluble in water and therefore is formulated in a lipid emulsion. In addition, a preservative (ethylenediaminetetraacetic acid [EDTA] or sodium metabisulfite) is added to retard bacterial growth. Propofol has antiinflammatory properties, decreasing production of proinflammatory cytokines, altering expression of nitric oxide, and inhibiting neutrophil function. Propofol also is a potent antioxidant. The added preservatives have biologic activity; EDTA has antiinflammatory properties, whereas metabisulfite may cause lipid peroxidation. The antiinflammatory and antioxidant properties of propofol may have beneficial effects in patients with sepsis and systemic inflammatory response syndrome.

引用

页码：28S / 33S

页数：6

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