Eradication Therapies for HIV Infection: Time to Begin Again

被引：33

作者：

Margolis, David M. ^{[1
]}

机构：

[1] Univ N Carolina, Inst Global Hlth & Infect Dis, Dept Med Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2011年 / 27卷 / 04期

基金：

美国国家卫生研究院;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; CD4(+) T-CELLS; ACTIVE ANTIRETROVIRAL THERAPY; REPLICATION-COMPETENT HIV; CENTRAL-NERVOUS-SYSTEM; LONG TERMINAL REPEAT; REVERSE-TRANSCRIPTASE; PROGENITOR CELLS; GENE-EXPRESSION; RESERVOIR;

D O I：

10.1089/aid.2011.0017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite the success of antiretroviral therapy (ART) in decreasing mortality for HIV-1-infected patients, ART has not cured the disease. A persistent viral reservoir in the T cells of HIV patients receiving potent ART is a significant barrier preventing eradication of HIV infection. We will briefly review what is known about the mechanisms that establish and maintain persistent HIV infection despite ART, to create a framework in which to consider approaches to the clearance or eradication of infection ("cure"), or to allow clinical stability in the absence of ART ("functional cure"). With regard to eradication therapies, it could be said that as a field our position is analogous to that of ART early in the HIV pandemic. As then we must now simultaneously develop and optimize platforms and paradigms for the discovery and testing of eradication therapies, and begin to advance candidate therapies toward human testing.

引用

页码：347 / 353

页数：7

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