Wood dust and nasal cancer risk - A review of the evidence from North America

被引:38
作者
Blot, WJ [1 ]
Chow, WH [1 ]
McLaughlin, JK [1 ]
机构
[1] INT EPIDEMIOL INST LTD,ROCKVILLE,MD 20850
关键词
D O I
10.1097/00043764-199702000-00012
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
In this article, biomedical literature assessing risks of nasal cancer and nonmalignant nasal pathology among woodworkers in North America is reviewed in detail and contrasted with experience from Europe and elsewhere. Exceptionally high rates of nasal adenocarcinoma have occurred among European hardwood furniture workers, but the epidemiologic evidence documents a disparity in findings between North America and Europe. Cohort studies of American wood-dust-exposed groups do not reveal excesses of nasal cancer, and wood-dust associations from US and Canadian case-control studies of nasal cancer tend not to be strong and differ across studies. Quantitative wood-dust exposure data are generally unavailable, but general dose information in European studies suggests that the excess risk of nasal cancer is associated with high levels of exposure. There is also an inconsistent association between wood-dust exposure per se and mucostasis or nasal histologic changes, and the mucostasis/metaplasia/dysplasia route to nasal cancer is still an unverified hypothesis. Considering the totality of evidence on the risk of cancer in exposed workers, it appears that wood-dust-related nasal adenocarcinoma essentially can be eliminated in Europe and its occurrence prevented in the United States if wood-dust exposures do not exceed an 8-hour time-weighted average 5 mg/m(3) standard.
引用
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页码:148 / 156
页数:9
相关论文
共 51 条
  • [11] BLACK A, 1974, BRIT J IND MED, V31, P10
  • [12] BLAIR A, 1986, J NATL CANCER I, V76, P1071
  • [13] CHANGES IN THE NASAL-MUCOSA OF FURNITURE WORKERS - A PILOT-STUDY
    BOYSEN, M
    SOLBERG, LA
    [J]. SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, 1982, 8 (04) : 273 - 282
  • [14] THE NASAL-MUCOSA IN SOFTWOOD EXPOSED FURNITURE WORKERS
    BOYSEN, M
    VOSS, R
    SOLBERG, LA
    [J]. ACTA OTO-LARYNGOLOGICA, 1986, 101 (5-6) : 501 - 508
  • [15] A CASE-CONTROL STUDY OF CANCERS OF THE NASAL CAVITY AND PARA-NASAL SINUSES
    BRINTON, LA
    BLOT, WJ
    BECKER, JA
    WINN, DM
    BROWDER, JP
    FARMER, JC
    FRAUMENI, JF
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1984, 119 (06) : 896 - 906
  • [16] BRINTON LA, 1977, CANCER RES, V37, P3473
  • [17] COMBA P, 1992, BRIT J IND MED, V49, P193
  • [18] A CASE-CONTROL STUDY OF CANCER OF THE NOSE AND PARANASAL SINUSES AND OCCUPATIONAL EXPOSURES
    COMBA, P
    BATTISTA, G
    BELLI, S
    DECAPUA, B
    MERLER, E
    ORSI, D
    RODELLA, S
    VINDIGNI, C
    AXELSON, O
    [J]. AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, 1992, 22 (04) : 511 - 520
  • [19] CORREA P, 1992, CANCER RES, V52, P6735
  • [20] POOLED REANALYSIS OF CANCER MORTALITY AMONG 5 COHORTS OF WORKERS IN WOOD-RELATED INDUSTRIES
    DEMERS, PA
    BOFFETTA, P
    KOGEVINAS, M
    BLAIR, A
    MILLER, BA
    ROBINSON, CF
    ROSCOE, RJ
    WINTER, PD
    COLIN, D
    MATOS, E
    VAINIO, H
    [J]. SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, 1995, 21 (03) : 179 - 190