Inflammaging and Frailty Status Do Not Result in an Increased Extracellular Vesicle Concentration in Circulation

被引：27

作者：

Alberro, Ainhoa ^{[1
]}

Saenz-Cuesta, Matias ^{[1
,2
]}

Munoz-Culla, Maider ^{[1
,2
]}

Mateo-Abad, Maider ^{[3
]}

Gonzalez, Esperanza ^{[4
]}

Carrasco-Garcia, Estefania ^{[5
]}

Arauzo-Bravo, Marcos J. ^{[6
,7
]}

Matheu, Ander ^{[5
,7
]}

Vergara, Itziar ^{[3
,8
]}

Otaegui, David ^{[1
,2
]}

机构：

[1] Donostia Univ Hosp, Multiple Sclerosis Unit, Biodonostia Hlth Res Inst, San Sebastian 20014, Spain

[2] Spanish Network Multiple Sclerosis, Barcelona 08028, Spain

[3] Biodonostia Hlth Res Inst, Primary Care Res Unit Gipuzkoa, Osakidetza, San Sebastian 20014, Spain

[4] CIBERehd, Metabol Unit, CIC BioGUNE, Technol Pk Bizkaia, Bizkaia 48980, Spain

[5] Biodonostia Hlth Res Inst, Cellular Oncol Grp, San Sebastian 20014, Spain

[6] Biodonostia Hlth Res Inst, Computat Biol & Syst Biomed Grp, San Sebastian 20014, Spain

[7] Basque Fdn Sci, IKERBASQUE, Bilbao 48015, Spain

[8] Hlth Serv Res Chron Patients Network REDISSEC, Bilbao 48013, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 07期

关键词：

extracellular vesicle; intercellular communication; human aging; inflammaging; frailty; interleukin-6; MICROVESICLES; EXOSOMES;

D O I：

10.3390/ijms17071168

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In the last decades extracellular vesicles (EVs) have emerged as key players for intercellular communication. In the case of inflammation, several studies have reported that EV levels are increased in circulation during inflammatory episodes. Based on this, we investigated whether aging results in elevated EV number, as a basal proinflammatory status termed inflammaging has been described in aged individuals. Moreover, we also hypothesized that frailty and dependence conditions of the elderly could affect EV concentration in plasma. Results showed that inflammaging, frailty or dependence status do not result in EV increase, at least in the total number of EVs in circulation. These results open a new perspective for investigating the role of EVs in human aging and in the inflammaging process.

引用

页数：7

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