Gold(I)-catalyzed additions of three-component 2-(arylmethylene)cyclopropylcarbinols, terminal arynes, and alcohols: An efficient access to 3-oxabicyclo[3.1.0]hexanes

被引：65

作者：

Tian, Guo-Qiang ^{[1
]}

Shi, Min ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 23期

关键词：

D O I：

10.1021/ol702341a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalyzed by gold(I), (E)- and (Z)-2-(arylmethylene)cyclopropylcarbinols, terminal arynes, and alcohols underwent three-component addition reactions to produce 3-oxabicyclo[3.1.0]hexanes in high yields and moderate diastereoselectivities under mild conditions. A plausible mechanism based on an intermolecular tandem hydroalkoxylation/Prins-type reaction pathway has been proposed.

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页码：4917 / 4920

页数：4

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