Studies toward the total synthesis of the cytotoxic sponge alkaloid pyrinodemin A

被引：25

作者：

Baldwin, JE ^{[1
]}

Romeril, SP ^{[1
]}

Lee, V ^{[1
]}

Claridge, TDW ^{[1
]}

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 08期

关键词：

D O I：

10.1021/ol015646q

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

The syntheses of the proposed structure of pyrinodemin A (1) and its cis double bond positional isomer (C15'-C16') in racemic form are described. The key reaction involved an intramolecular nitrone/double bond cycloaddition. Our results suggest that neither 1 nor its double positional isomer is the correct structure of pyrinodemin A.

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页码：1145 / 1148

页数：4

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