Evaluation of methods for the prediction of membrane spanning regions

被引：1000

作者：

Möller, S

Croning, MDR

Apweiler, R

机构：

[1] EMBL, Outstn European Bioinformat Inst, Cambridge CB10 1SD, England

[2] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

来源：

BIOINFORMATICS | 2001年 / 17卷 / 07期

关键词：

D O I：

10.1093/bioinformatics/17.7.646

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: A variety of tools are available to predict the topology of transmembrane proteins. To date no independent evaluation of the performance of these tools has been published. A better understanding of the strengths and weaknesses of the different tools would guide both the biologist and the bioinformatician to make better predictions of membrane protein topology. Results: Here we present an evaluation of the performance of the currently best known and most widely used methods for the prediction of transmembrane regions in proteins. Our results show that TMHMM is currently the best performing transmembrane prediction program.

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收藏

页码：646 / 653

页数：8

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