Synthesis and microtubule binding of fluorescent paclitaxel derivatives

被引：14

作者：

Baloglu, E

Kingston, DGI

Patel, P

Chatterjee, SK

Bane, SL ^{[1
]}

机构：

[1] SUNY Binghamton, Dept Chem, Binghamton, NY 13902 USA

[2] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(01)00453-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation of two new fluorescent derivatives of paclitaxel in which the fluorophore is bonded to paclitaxel at the C-10 position is reported, Both analogues, 10-deacetyl-10-(m-aminobenzoyl)paclitaxel (1, BTax) and 10-dcacetyl-10-[7-(diethylamino) coumarin-3-carbonyl]paclitaxel (2, CTax) retain good activity as promoters of in vitro tubulin assembly. Microtubule binding enhances the emission intensity of both probes. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：2249 / 2252

页数：4

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