Synergistic killing of streptococcus pneumoniae with the bacteriophage lytic enzyme Cpl-1 and penicillin or gentamicin depends on the level of penicillin resistance

被引:78
作者
Djurkovic, S
Loeffler, JA
Fischetti, VA
机构
[1] Rockefeller Univ, Lab Bacterial Pathogenesis, New York, NY 10021 USA
[2] Sloan Kettering Canc Inst, Div Infect Dis, New York, NY USA
关键词
D O I
10.1128/AAC.49.3.1225-1228.2005
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
A combination of Cpl-1, a bacteriophage lytic enzyme, and penicillin, gentamicin, levofloxacin, or azithromycin was tested against Streptococcus pneumoniae strains with various susceptibilities to penicillin. Activities of Cpl-1 and gentamicin were increasingly synergistic with a decreasing penicillin MIC, while Cpl-1 and penicillin showed synergy against an extremely penicillin-resistant strain.
引用
收藏
页码:1225 / 1228
页数:4
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