Synergistic killing of streptococcus pneumoniae with the bacteriophage lytic enzyme Cpl-1 and penicillin or gentamicin depends on the level of penicillin resistance

被引：78

作者：

Djurkovic, S

Loeffler, JA

Fischetti, VA

机构：

[1] Rockefeller Univ, Lab Bacterial Pathogenesis, New York, NY 10021 USA

[2] Sloan Kettering Canc Inst, Div Infect Dis, New York, NY USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 03期

关键词：

D O I：

10.1128/AAC.49.3.1225-1228.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A combination of Cpl-1, a bacteriophage lytic enzyme, and penicillin, gentamicin, levofloxacin, or azithromycin was tested against Streptococcus pneumoniae strains with various susceptibilities to penicillin. Activities of Cpl-1 and gentamicin were increasingly synergistic with a decreasing penicillin MIC, while Cpl-1 and penicillin showed synergy against an extremely penicillin-resistant strain.

引用

页码：1225 / 1228

页数：4

共 13 条

[11] Prevention and elimination of upper respiratory colonization of mice by group A streptococci by using a bacteriophage lytic enzyme [J].