Cancer chemopreventive activity of an iridoid glycoside, 8-acetylharpagide, from Ajuga decumbens

被引：94

作者：

Konoshima, T ^{[1
]}

Takasaki, M

Tokuda, H

Nishino, H

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078414, Japan

[2] Kyoto Prefectural Univ Med, Kamigyo Ku, Kyoto 6020841, Japan

来源：

CANCER LETTERS | 2000年 / 157卷 / 01期

关键词：

cancer chemopreventive activity; 8-acetylharpagide; Ajuga decumbens; nitric oxide donor; (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexeneamide; hepatic tumor inhibitor;

D O I：

10.1016/S0304-3835(00)00479-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Labiatae plants were screened. Consequently, the iridoid glycoside derivative, 8-acetylharpagide (8-AcHarp), was obtained from the flowering whole plant of Ajuda decumbens as an active constituent. This glycoside exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mo use skin tumors induced by nitric oxide (NO) donor, (+/-)-(E)-methyl-2-[(E)hydroxyimino]-5-nitro-6-methoxy-3-hexeneamide (NOR 1) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Further, 8-AcHarp exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse hepatic tumor using N-nitrosodiethylamine (DEN) as an initiator and phenobarbital (PB) as a promoter. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：87 / 92

页数：6

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