Cell fusion during development

被引：94

作者：

Oren-Suissa, Meital ^{[1
]}

Podbilewicz, Benjamin ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Dept Biol, IL-32000 Haifa, Israel

来源：

TRENDS IN CELL BIOLOGY | 2007年 / 17卷 / 11期

基金：

以色列科学基金会;

关键词：

D O I：

10.1016/j.tcb.2007.09.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most readers of this review originated from a sperm-egg fusion event. Cell fusion is a process that is crucial at many intersections later during development. However, we do not know which molecules (fusogens) fuse the membranes of gametes to form zygotes, myoblasts to form myotubes in muscles, macrophages to form osteoclasts in bones, or cytotrophoblasts to form syncytiotrophoblasts in placentas. There are five gold standards that can be applied for the identification of genuine fusogens. Based on these criteria, a numerical score can be used to assess the likelihood of protein fusogenicity. We compare distinct families of candidate developmental, viral and intracellular fusogens and analyze current models of membrane fusion.

引用

页码：537 / 546

页数：10

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