Tunable thermo-responsive polymer-protein conjugates via a combination of nucleophilic thiol-ene "click" and SET-LRP

被引：85

作者：

Jones, Mathew W. ^{[1
]}

Gibson, Matthew I. ^{[1
]}

Mantovani, Giuseppe ^{[2
]}

Haddleton, David M. ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England

来源：

POLYMER CHEMISTRY | 2011年 / 2卷 / 03期

基金：

英国工程与自然科学研究理事会;

关键词：

LIVING RADICAL POLYMERIZATION; ANIONIC POLYMERIZATIONS; PEGYLATION; METHACRYLATES; EFFICIENT; POINT;

D O I：

10.1039/c0py00329h

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Herein we report the synthesis of a protein macroinitiator in a one-pot strategy using phosphine-mediated thiol-ene "click", the macroinitiator was used to polymerise ethylene glycol containing monomers to yield polymer-protein conjugates with tunable thermoresponsive behaviour.

引用

页码：572 / 574

页数：3

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