Extended-spectrum cephalosporinases: structure, detection and epidemiology

被引：77

作者：

Nordmann, Patrice

Mommeri, Hedi

机构：

[1] Hop Bicetre, Serv Bacteriol Virol, F-94275 Le Kremlin Bicetre, France

[2] Univ Picardie Jules Verne, Fac Med, Hop Nord, CHU Amiens,Serv Bacteriol, F-80000 Amiens, France

来源：

FUTURE MICROBIOLOGY | 2007年 / 2卷 / 03期

关键词：

AmpC; carbapenem; cefepime; cephalosporin; extended-spectrum AmpC beta-lactamases; extended-spectrum cephalosporinase;

D O I：

10.2217/17460913.2.3.297

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Extended-spectrum AmpC beta-lactamases of Enterobacteriaceae, which are chromosomally or plasmid-encoded, possess structural modifications in the vicinity of the active site compared with their progenitors. They display an increased catalytic efficiency against extended-spectrum beta-lactams, such as ceffazidime, cefotaxime, cefepime, cefpirome and, in some cases, also against imipenem. An overview of the molecular and biochemical characterization of this recently identified mechanism of resistance to beta-lactams is provided as well as its prevalence and possible clinical significance.

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页码：297 / 307

页数：11

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