Oropharyngeal cancer pathogenesis: Ubiquitin proteolytic, apoptotic and epidermal growth factor related pathways act in concert - first report

被引：14

作者：

Ben-Izhak, O

Kablan, F

Laster, Z

Nagler, RM

机构：

[1] Rambam Med Ctr, Dept Oral & Maxillofacial Surg, Haifa, Israel

[2] Rambam Med Ctr, Oral Biochem Lab, Haifa, Israel

[3] Rambam Med Ctr, Dept Pathol, Haifa, Israel

[4] Technion Israel Inst Technol, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel

来源：

ORAL ONCOLOGY | 2005年 / 41卷 / 08期

关键词：

oral cancer; apoptosis; ubiquitin; p27; Skp2; c-erbB-2; p53; Bcl-2;

D O I：

10.1016/j.oraloncology.2005.04.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The current study was carried out to examine the clinical characteristics and survival-probability rates of 51 patients treated for oral (tongue) cancer and to correlate it with various tumor markers. The clinical data and survival probability rates were correlated with the immunohistological analysis of p27, Skp2, p53, Bcl-2, TUNEL (apoptotic rate) and c-erbB-2 markers. The 5-year survival-probability correlated with staging, grading and base of tongue location. An inverse relation between the expression of p27 and Skp2, p27 and grading, and a direct relation between Skp2 and grading were demonstrated. Concomitantly, significant correlations between low p27, high Skp2 and high TUNEL (apoptotic rate) expressions and between low p27 and high c-erbB-2 (Her2) expressions in the cancer lesions were demonstrated. The accumulated data may be employed in the future for a better understanding of the biology behind oral cancer and for developing better means of detection and treatment. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：851 / 860

页数：10

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