Amino acids as regulators of gene expression: molecular mechanisms

被引：88

作者：

Jousse, C ^{[1
]}

Averous, J ^{[1
]}

Bruhat, A ^{[1
]}

Carraro, V ^{[1
]}

Mordier, S ^{[1
]}

Fafournoux, P ^{[1
]}

机构：

[1] INRA, Unite Nutr & Metab Prot, F-63122 St Genes Champanelle, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 313卷 / 02期

关键词：

amino acids; gene expression; CHOP; asparagine synthetase; IGFBP-1; protein under-nutrition;

D O I：

10.1016/j.bbrc.2003.07.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulation of gene expression by nutrients in mammals is an important mechanism allowing them to adapt their physiological functions according to the supply of nutrient in the diet. It has been shown recently that amino acids are able to regulate by themselves the expression of numerous genes. CHOP, asparagine synthetase, and IGFBP-1 regulation following AA starvation will be described in this review with special interest in the molecular mechanisms involved. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：447 / 452

页数：6

共 43 条

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