Intracellular Glutathione Detection Using MnO2-Nanosheet-Modified Upconversion Nanoparticles

被引：1026

作者：

Deng, Renren ^{[1
]}

Xie, Xiaoji ^{[1
]}

Vendrell, Marc ^{[4
]}

Chang, Young-Tae ^{[1
,2
,4
]}

Liu, Xiaogang ^{[1
,3
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] Natl Univ Singapore, MedChem Program, Inst Life Sci, Singapore 117543, Singapore

[3] Inst Mat Res & Engn, Singapore 117602, Singapore

[4] ASTAR, Singapore Bioimaging Consortium, Lab Bioimaging Probe Dev, Singapore 138667, Singapore

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 50期

关键词：

UPCONVERTING NANOPARTICLES; ENERGY-TRANSFER; NANOCRYSTALS; LUMINESCENCE; NANOPHOSPHORS; ASSAY; SHAPE; SIZE; PHOTOLUMINESCENCE; ELECTRODES;

D O I：

10.1021/ja2100774

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

We report a novel design, based on a combination of lanthanide-doped upconversion nanoparticles and manganese dioxide nanosheets, for rapid, selective detection of glutathione in aqueous solutions and living cells. In this approach, manganese dioxide (MnO2) nanosheets formed on the surface of nanoparticles serve as an efficient quencher for upconverted luminescence. The luminescence can be turned on by introducing glutathione that reduces MnO2 into Mn2+. The ability to monitor the glutathione concentration intracellularly may enable rational design of a convenient platform for targeted drug and gene delivery.

引用

页码：20168 / 20171

页数：4

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