Influenza vaccination in heart transplant recipients

被引：42

作者：

Fraund, S ^{[1
]}

Wagner, D ^{[1
]}

Pethig, K ^{[1
]}

Drescher, J ^{[1
]}

Girgsdies, OE ^{[1
]}

Haverich, A ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Thorac & Cardiovasc Surg, Div Surg, Marburg, Germany

来源：

JOURNAL OF HEART AND LUNG TRANSPLANTATION | 1999年 / 18卷 / 03期

关键词：

D O I：

10.1016/S1053-2498(98)00013-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Seventy-nine heart transplant recipients were vaccinated with a trivalent influenza virus vaccine 1996/97 containing the strains A/Singapore/6/86 (H1N1), A/Wuhan/395/95 (H3N2), and B/Beijing/184/93. The proportions of patients with protective levels of antibody (HI greater than or equal to 40) after vaccination ranged from 100% (A/Singapore [H1N1]) to 31.6% (B/Beijing) and their mean fold titer increases were lower than those recorded for vaccination of 109 healthy subjects with the same batch of vaccine. The vaccinations were tolerated well and did not result in serious side effects, such as graft rejections. Our findings indicate that influenza vaccination can induce protective antibody levels in a substantial proportion of heart transplant recipients and lend support to the recommendation to vaccinate such patients annually against influenza.

引用

页码：220 / 225

页数：6

共 23 条

[11] SPECIFIC IMMUNITY IN INFLUENZA - SUMMARY OF INFLUENZA WORKSHOP 3 [J].

KILBOURNE, ED ;

BUTLER, WT ;

ROSSEN, RD .

JOURNAL OF INFECTIOUS DISEASES, 1973, 127 (02) :220-236

[12]

KOBASHIGAWA JA, 1993, TRANSPLANT P, V25, P2738

[13]

KUMAR SS, 1978, JAMA-J AM MED ASSOC, V239, P840

[14] INFLUENZA-A IN IMMUNOCOMPROMISED PATIENTS [J].

LJUNGMAN, P ;

ANDERSSON, J ;

ASCHAN, J ;

BARKHOLT, L ;

EHRNST, A ;

JOHANSSON, M ;

WEILAND, O .

CLINICAL INFECTIOUS DISEASES, 1993, 17 (02) :244-247

[15]

MASUREL N, 1969, LANCET, V1, P907

[16]

MAUCH TJ, 1994, PEDIATRICS, V94, P225

[17] ANTIBODY-RESPONSE TO INFLUENZA VACCINATION IN RENAL-TRANSPLANT PATIENTS - CORRELATION WITH ALLOGRAFT FUNCTION [J].

PABICO, RC ;

DOUGLAS, RG ;

BETTS, RF ;

MCKENNA, BA ;

FREEMAN, RB .

ANNALS OF INTERNAL MEDICINE, 1976, 85 (04) :431-436

[18]

PALMER DF, 1976, ADV LAB TECHNIQUES I, P85

[19] INFLUENZA SUBTYPE-SPECIFIC IGA, IGM AND IGG RESPONSES IN PATIENTS ON HEMODIALYSIS AFTER INFLUENZA VACCINATION [J].

RAUTENBERG, P ;

TEIFKE, I ;

SCHLEGELBERGER, T ;

ULLMANN, U .

INFECTION, 1988, 16 (06) :323-328

[20]

Rytel M W, 1977, Dev Biol Stand, V39, P225

← 1 2 3 →