Haptoglobin, inflammation and disease

被引：277

作者：

Quaye, Isaac K. ^{[1
]}

机构：

[1] Univ Ghana, Sch Med, Dept Med Biochem, Korle Bu Accra, Ghana

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2008年 / 102卷 / 08期

关键词：

haptoglobin; haemoglobin; phenotype; immune response; inflammation; infectious diseases;

D O I：

10.1016/j.trstmh.2008.04.010

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Haptoglobin is an acute phase protein that scavenges haemoglobin in the event of intravascular or extravascular haemolysis. The protein exists in humans as three main phenotypes, Hpl-1, Hp2-2 and Hp2-1. Accumulated data on the protein's function has established its strong association with diseases that have inflammatory causes. These include parasitic (malaria), infectious (HIV, tuberculosis) and non-infectious diseases (diabetes, cardiovascular disease and obesity) among others. Phenotype-dependent poor disease outcomes have been [inked with the Hp2-2 phenotype. The present review brings this association into perspective by looking at the functions of the protein and how defects in these functions associated with the Hp2 allele affect disease outcome. A model is provided to explain the mechanism, which appears to be largely immunomodutatory. (c) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：735 / 742

页数：8

共 78 条

[1] Redox biology of blood [J].

Alayash, AI .

ANTIOXIDANTS & REDOX SIGNALING, 2004, 6 (06) :941-943

[2] Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release [J].

Arredouani, M ;

Matthijs, P ;

Van Hoeyveld, E ;

Kasran, A ;

Baumann, H ;

Ceuppens, JL ;

Stevens, E .

IMMUNOLOGY, 2003, 108 (02) :144-151

[3] Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype [J].

Atkinson, Sarah H. ;

Rockett, Kirk ;

Sirugo, Giorgio ;

Bejon, Philip A. ;

Fulford, Anthony ;

O'Connell, Maria A. ;

Bailey, Robin ;

Kwiatkowski, Dominic P. ;

Prentice, Andrew M. .

PLOS MEDICINE, 2006, 3 (05) :652-658

[4] The haptoglobin 2-2 genotype is associated with a reduced incidence of Plasmodium falciparum malaria in children on the coast of Kenya [J].

Atkinson, Sarah H. ;

Mwangi, Tabitha W. ;

Uyoga, Sophie M. ;

Ogada, Edna ;

Macharia, Alex W. ;

Marsh, Kevin ;

Prentice, Andrew M. ;

Williams, Thomas N. .

CLINICAL INFECTIOUS DISEASES, 2007, 44 (06) :802-809

[5] Haptoglobin genotypes are not associated with resistance to severe malaria in The Gambia [J].

Aucan, C ;

Walley, AJ ;

Greenwood, BM ;

Hill, AVS .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2002, 96 (03) :327-328

[6] DISTINCT REGULATION OF THE INTERLEUKIN-1 AND INTERLEUKIN-6 RESPONSE ELEMENTS OF THE RAT HAPTOGLOBIN GENE IN RAT AND HUMAN HEPATOMA-CELLS [J].

BAUMANN, H ;

MORELLA, KK ;

JAHREIS, GP ;

MARINKOVIC, S .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (11) :5967-5976

[7] Haptoglobin is present in human endometrium and shows elevated levels in the decidua during pregnancy [J].

Berkova, N ;

Lemay, A ;

Dresser, DW ;

Fontaine, JY ;

Kerizit, J ;

Goupil, S .

MOLECULAR HUMAN REPRODUCTION, 2001, 7 (08) :747-754

[8] DAMPs, PAMPs and alarmins: all we need to know about danger [J].

Bianchi, Marco E. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2007, 81 (01) :1-5

[9] Short Communication: Limited influence of haptoglobin genotypes on severe malaria in Ghanaian children [J].

Bienzle, U ;

Eggelte, TA ;

Adjei, LA ;

Dietz, E ;

Ehrhardt, S ;

Cramer, JP ;

Otchwemah, RN ;

Mockenhaupt, FP .

TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2005, 10 (07) :668-671

[10] Haptoglobin genotype determines myocardial infarct size in diabetic mice [J].

Blum, Shany ;

Asaf, Roy ;

Guetta, Julia ;

Miller-Lotan, Rachel ;

Asleh, Rabea ;

Kremer, Ran ;

Levy, Nina S. ;

Berger, Franklin G. ;

Aronson, Doron ;

Fu, Xiaoming ;

Zhang, Renliang ;

Hazen, Stanley L. ;

Levy, Andrew P. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (01) :82-87

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