Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood

被引：125

作者：

Wang, Bo ^{[1
]}

Karpiouk, Andrei ^{[1
]}

Yeager, Doug ^{[1
]}

Amirian, James ^{[2
]}

Litovsky, Silvio ^{[3
]}

Smalling, Richard ^{[2
]}

Emelianov, Stanislav ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78731 USA

[2] Univ Texas Hlth Sci Ctr, Div Cardiol, Houston, TX 77030 USA

[3] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35249 USA

来源：

OPTICS LETTERS | 2012年 / 37卷 / 07期

基金：

美国国家卫生研究院;

关键词：

OPTICAL-COHERENCE-TOMOGRAPHY; NEAR-INFRARED SPECTROSCOPY; ULTRASOUND; CATHETER;

D O I：

10.1364/OL.37.001244

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Intravascular photoacoustic (IVPA) imaging can characterize atherosclerotic plaque composition on the basis of the optical absorption contrast between different tissue types. Given the high optical absorption of lipid at 1720 nm wavelength, an atherosclerotic rabbit aorta was imaged at this wavelength ex vivo using an integrated intravascular ultrasound (IVUS) and IVPA imaging catheter in the presence of luminal blood. Strong optical absorption of lipid combined with low background signal from other tissues provides a high-contrast, depth-resolved IVPA image of lipid. The ability to image lipid at a single wavelength without removing luminal blood suggests that in vivo detection of lipid in atherosclerotic plaques using combined IVUS/IVPA imaging is possible. (C) 2012 Optical Society of America

引用

页码：1244 / 1246

页数：3

共 18 条

[1] Photoacoustic characterisation of vascular tissue at NIR wavelengths. [J].

Allen, Thomas J. ;

Beard, Paul C. .

PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2009, 2009, 7177

[2] Selective photothermolysis of lipid-rich tissues: A free electron laser study [J].

Anderson, R. Rox ;

Farinelli, William ;

Laubach, Hans ;

Manstein, Dieter ;

Yaroslavsky, Anna N. ;

Gubeli, Joseph, III ;

Jordan, Kevin ;

Neil, George R. ;

Shinn, Michelle ;

Chandler, Walter ;

Williams, Gwyn P. ;

Benson, Steven V. ;

Douglas, David R. ;

Dylla, H. F. .

LASERS IN SURGERY AND MEDICINE, 2006, 38 (10) :913-919

[3] Near-infrared spectroscopy for the detection of vulnerable coronary artery plaques [J].

Caplan, JD ;

Waxman, S ;

Nesto, RW ;

Muller, JE .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (08) :C92-C96

[4]

Cheng-Lun Tsai, 2001, Journal of Medical and Biological Engineering, V21, P7

[5] Pathogenesis of atherosclerosis [J].

Falk, E .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (08) :C7-C12

[6] Detection of Lipid Core Coronary Plaques in Autopsy Specimens With a Novel Catheter-Based Near-Infrared Spectroscopy System [J].

Gardner, Craig M. ;

Tan, Huwei ;

Hull, Edward L. ;

Lisauskas, Jennifer B. ;

Sum, Stephen T. ;

Meese, Thomas M. ;

Jiang, Chunsheng ;

Madden, Sean P. ;

Caplan, Jay D. ;

Burke, Allen P. ;

Virmani, Renu ;

Goldstein, James ;

Muller, James E. .

JACC-CARDIOVASCULAR IMAGING, 2008, 1 (05) :638-648

[7] Use of an oxygen-carrying blood substitute to improve intravascular optical coherence tomography imaging [J].

Hoang, Khiet C. ;

Edris, Ahmad ;

Su, Jianping ;

Mukai, David S. ;

Mahon, Sari ;

Petrov, Artiom D. ;

Kern, Morton ;

Ashan, Chowdhury ;

Chen, Zhongping ;

Tromberg, Bruce J. ;

Narula, Jagat ;

Brenner, Matthew .

JOURNAL OF BIOMEDICAL OPTICS, 2009, 14 (03)

[8] Intravascular photoacoustic imaging of human coronary atherosclerosis [J].

Jansen, Krista ;

van der Steen, Antonius F. W. ;

van Beusekom, Heleen M. M. ;

Oosterhuis, J. Wolter ;

van Soest, Gijs .

OPTICS LETTERS, 2011, 36 (05) :597-599

[9] Development of a catheter for combined intravascular ultrasound and photoacoustic imaging [J].

Karpiouk, Andrei B. ;

Wang, Bo ;

Emelianov, Stanislav Y. .

REVIEW OF SCIENTIFIC INSTRUMENTS, 2010, 81 (01)

[10] In vivo volumetric analysis of coronary stent using optical coherence tomography with a novel balloon occlusion-flushing catheter:: A comparison with intravascular ultrasound [J].

Kawase, Y ;

Hoshino, K ;

Yoneyama, R ;

McGregor, J ;

Hajjar, RJ ;

Jang, IK ;

Hayase, M .

ULTRASOUND IN MEDICINE AND BIOLOGY, 2005, 31 (10) :1343-1349

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