An international standardization programme towards the application of gene expression profiling in routine leukaemia diagnostics: the Microarray Innovations in LEukemia study prephase

被引：159

作者：

Kohlmann, Alexander ^{[1
]}

Kipps, Thomas J. ^{[2
]}

Rassenti, Laura Z. ^{[2
]}

Downing, James R. ^{[3
]}

Shurtleff, Sheila A. ^{[3
]}

Mills, Ken I. ^{[4
]}

Gilkes, Amanda F. ^{[4
]}

Hofmann, Wolf-Karsten ^{[5
]}

Basso, Giuseppe ^{[6
]}

Dell'Orto, Marta Campo ^{[6
]}

Foa, Robin ^{[7
]}

Chiaretti, Sabina ^{[7
]}

De Vos, John ^{[8
]}

Rauhut, Sonja ^{[9
]}

Papenhausen, Peter R.

Hernandez, Jesus M. ^{[10
,11
]}

Lumbreras, Eva ^{[10
,11
]}

Yeoh, Allen E. ^{[12
,13
]}

Koay, Evelyn S. ^{[12
,13
]}

Li, Rachel ^{[1
]}

Liu, Wei-Min ^{[1
]}

Williams, Paul M. ^{[1
]}

Wieczorek, Lothar ^{[1
]}

Haferlach, Torsten ^{[9
]}

机构：

[1] Roche Mol Syst Inc, Dept Genom Oncol, Pleasanton, CA 94588 USA

[2] Univ Calif San Diego, Moores Canc Ctr, San Diego, CA 92103 USA

[3] St Jude Childrens Hosp, Dept Pathol, Memphis, TN 38105 USA

[4] Cardiff Univ, Dept Haematol, Cardiff, Wales

[5] Univ Hosp Benjamin Franklin, Chairte, Berlin, Germany

[6] Univ Padua, Dept Paediat, Padua, Italy

[7] Univ Roma La Sapienza, Dept Cellular Biotechnol & Haematol, Div Haematol, Rome, Italy

[8] CHU Montpellier, Inst Rech Biotherapie, Montpellier, France

[9] Munich Leukemia Lab, Munich, Germany

[10] Univ Salamanca, CSIC, CIC, E-37008 Salamanca, Spain

[11] Hosp Univ Salamanca, Salamanca, Spain

[12] Natl Univ Singapore, Dept Pathol, Singapore 117548, Singapore

[13] Natl Univ Singapore, Dept Paediat, Singapore 117548, Singapore

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2008年 / 142卷 / 05期

关键词：

microarray; gene expression profiling; leukaemia; standardization; diagnostics;

D O I：

10.1111/j.1365-2141.2008.07261.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gene expression profiling has the potential to enhance current methods for the diagnosis of haematological malignancies. Here, we present data on 204 analyses from an international standardization programme that was conducted in 11 laboratories as a prephase to the Microarray Innovations in LEukemia (MILE) study. Each laboratory prepared two cell line samples, together with three replicate leukaemia patient lysates in two distinct stages: (i) a 5-d course of protocol training, and (ii) independent proficiency testing. Unsupervised, supervised, and r(2) correlation analyses demonstrated that microarray analysis can be performed with remarkably high intra-laboratory reproducibility and with comparable quality and reliability.

引用

页码：802 / 807

页数：6

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