tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration

被引：236

作者：

Kikuchi, Kazu

Gupta, Vikas

Wang, Jinhu

Holdway, Jennifer E.

Wills, Airon A.

Fang, Yi

Poss, Kenneth D. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA

来源：

DEVELOPMENT | 2011年 / 138卷 / 14期

关键词：

Heart regeneration; Heart development; Cardiomyocyte; Epicardium; Zebrafish; Genetic fate-mapping; SMOOTH-MUSCLE-CELLS; CONTRIBUTE; MESENCHYME; LINEAGE; FIBROBLASTS; PROGENITORS; POPULATION; CAPSULIN; LESSONS; KIDNEY;

D O I：

10.1242/dev.067041

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Recent lineage-tracing studies have produced conflicting results about whether the epicardium is a source of cardiac muscle cells during heart development. Here, we examined the developmental potential of epicardial tissue in zebrafish during both embryonic development and injury-induced heart regeneration. We found that upstream sequences of the transcription factor gene tcf21 activated robust, epicardium-specific expression throughout development and regeneration. Cre recombinase-based, genetic fate-mapping of larval or adult tcf21(+) cells revealed contributions to perivascular cells, but not cardiomyocytes, during each form of cardiogenesis. Our findings indicate that natural epicardial fates are limited to non-myocardial cell types in zebrafish.

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收藏

页码：2895 / 2902

页数：8

相关论文

共 33 条

[1]

Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury [J].

Bersell, Kevin ;

Arab, Shima ;

Haring, Bernhard ;

Kuehn, Bernhard .

CELL, 2009, 138 (02) :257-270

[2]

High-throughput assay for small molecules that modulate zebrafish embryonic heart rate [J].

Burns, CG ;

Milan, DJ ;

Grande, EJ ;

Rottbauer, W ;

MacRae, CA ;

Fishman, MC .

NATURE CHEMICAL BIOLOGY, 2005, 1 (05) :263-264

[3]

A myocardial lineage derives from Tbx18 epicardial cells [J].

Cai, Chen-Leng ;

Martin, Jody C. ;

Sun, Yunfu ;

Cui, Li ;

Wang, Lianchun ;

Ouyang, Kunfu ;

Yang, Lei ;

Bu, Lei ;

Liang, Xingqun ;

Zhang, Xiaoxue ;

Stallcup, William B. ;

Denton, Christopher P. ;

McCulloch, Andrew ;

Chen, Ju ;

Evans, Sylvia M. .

NATURE, 2008, 454 (7200) :104-U4

[4]

Tbx18 and the fate of epicardial progenitors [J].

Christoffels, Vincent M. ;

Grieskamp, Thomas ;

Norden, Julia ;

Mommersteeg, Mathilda T. M. ;

Rudat, Carsten ;

Kispert, Andreas .

NATURE, 2009, 458 (7240) :E8-E9

[5]

Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts, and intermyocardial fibroblasts in the avian heart [J].

Dettman, RW ;

Denetclaw, W ;

Ordahl, CP ;

Bristow, J .

DEVELOPMENTAL BIOLOGY, 1998, 193 (02) :169-181

[6]

Epicardium-derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions [J].

Gittenberger-de Groot, AC ;

Peeters, MPFMV ;

Mentink, MMT ;

Gourdie, RG ;

Poelmann, RE .

CIRCULATION RESEARCH, 1998, 82 (10) :1043-1052

[7]

Cloning of capsulin, a basic helix-loop-helix factor expressed in progenitor cells of the pericardium and the coronary arteries [J].

Hidai, H ;

Bardales, R ;

Goodwin, R ;

Quertermous, T ;

Quertermous, EE .

MECHANISMS OF DEVELOPMENT, 1998, 73 (01) :33-43

[8]

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors [J].

Ieda, Masaki ;

Fu, Ji-Dong ;

Delgado-Olguin, Paul ;

Vedantham, Vasanth ;

Hayashi, Yohei ;

Bruneau, Benoit G. ;

Srivastava, Deepak .

CELL, 2010, 142 (03) :375-386

[9]

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation [J].

Jopling, Chris ;

Sleep, Eduard ;

Raya, Marina ;

Marti, Merce ;

Raya, Angel ;

Izpisua Belmonte, Juan Carlos .

NATURE, 2010, 464 (7288) :606-U168

[10]

Retinoic Acid Production by Endocardium and Epicardium Is an Injury Response Essential for Zebrafish Heart Regeneration [J].

Kikuchi, Kazu ;

Holdway, Jennifer E. ;

Major, Robert J. ;

Blum, Nicola ;

Dahn, Randall D. ;

Begemann, Gerrit ;

Poss, Kenneth D. .

DEVELOPMENTAL CELL, 2011, 20 (03) :397-404

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