Vertebrate neural induction

被引：109

作者：

HemmatiBrivanlou, A ^{[1
]}

Melton, D ^{[1
]}

机构：

[1] HARVARD UNIV, HOWARD HUGHES MED INST, DEPT BIOCHEM & MOL BIOL, CAMBRIDGE, MA 02138 USA

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 1997年 / 20卷

关键词：

default model; BMP4; follistatin; noggin; chordin;

D O I：

10.1146/annurev.neuro.20.1.43

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

During early vertebrate development, the cells of the ectoderm choose between two possible fates: neural and epidermal. The process of neural induction was discovered nearly 70 years ago in vertebrates, and molecular analyses in recent years using Xenopus laevis embryos have identified several secreted factors with direct neural-inducing ability. There is considerable evidence that the mechanism of neuralization by these inducing factors is under inhibitory control and involves derepression. This review focuses on factors involved in the specification of neural fate within the frame of the default model of neural induction.

引用

页码：43 / 60

页数：18

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