Some perspectives on modeling leukemia

被引：27

作者：

Afenya, EK

Bentil, DE

机构：

[1] Elmhurst Coll, Dept Math, Elmhurst, IL 60126 USA

[2] Univ Vermont, Dept Math & Stat, Burlington, VT 05401 USA

来源：

MATHEMATICAL BIOSCIENCES | 1998年 / 150卷 / 02期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0025-5564(98)10005-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A diffusion model of leukemia is presented. The space-occupying effects of leukemic cells during leukemic expansion is investigated. The analyses and simulations of the model suggest that acute leukemia is a state in which positions inhabited by colonies of normal cells are invaded by emerging colonies of abnormal cells. Normal cells are then driven to a state of extinction as leukemic cells evolve toward high and dominant steady state levels. (C) 1998 Elsevier Science Inc. All rights reserved.

引用

页码：113 / 130

页数：18

共 26 条

[1]

Adam J. A., 1996, SURVEY MODELS TUMOR, P15

[2]

Adam JA, 1996, MATH COMPUT MODEL, V23, P1, DOI 10.1016/0895-7177(96)00016-7

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