Histone deacetylases

被引：346

作者：

Marks, PA

Miller, T

Richon, VM

机构：

[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10021 USA

[2] Aton Pharma Inc, Tarrytown, NY USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2003年 / 3卷 / 04期

关键词：

D O I：

10.1016/S1471-4892(03)00084-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Post-translational modification of the histories of chromatin has a fundamental role in regulating gene expression. Enzymes involved in these epigenetic events include histone deacetylases (class I and class II), which can be inhibited by a structurally diverse group of small molecules. These histone deacetylase inhibitors induce growth arrest, differentiation and/or apoptosis of cancer cells in vitro and in vivo. Results of clinical trials with several of these agents have indicated that they are well tolerated at doses that have anti-tumour activity.

引用

页码：344 / 351

页数：8

共 52 条

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