Trifluoromethyl ketones as inhibitors of histone deacetylase

被引：144

作者：

Frey, RR ^{[1
]}

Wada, CK ^{[1
]}

Garland, RB ^{[1
]}

Curtin, ML ^{[1
]}

Michaelides, MR ^{[1
]}

Li, JL ^{[1
]}

Pease, LJ ^{[1
]}

Glaser, KB ^{[1
]}

Marcotte, PA ^{[1
]}

Bouska, JJ ^{[1
]}

Murphy, SS ^{[1
]}

Davidsen, SK ^{[1
]}

机构：

[1] Abbott Labs, Canc Res, Abbott Pk, IL 60064 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(02)00754-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Trifluoromethyl ketones were found to be inhibitors of histone deacetylases (HDACs). Optimization of this series led to the identification of submicromolar inhibitors Such as 20 that demonstrated antiproliferative effects against the HT1080 and MDA 435 cell lines. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：3443 / 3447

页数：5

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