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Mecamylamine-precipitated nicotine-withdrawal aversion in Lewis and Fischer 344 inbred rat strains

被引：29
作者：
Suzuki, T
Ise, Y
Maeda, J
Misawa, M
机构：
[1] Hoshi Univ, Sch Pharm, Dept Toxicol, Shinagawa Ku, Tokyo 1428501, Japan
[2] Hoshi Univ, Sch Pharm, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 369卷 / 02期
关键词：
conditioned place preference paradigm; mecamylamine; withdrawal aversion; physical dependence; nicotine; Lewis rat; Fischer; 344; rat;
D O I：
10.1016/S0014-2999(99)00086-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Many studies have indicated that Lewis and Fischer 344 inbred rat strains show marked differences in behavioral responses to abused drugs. In the present study, we sought to determine whether these two strains of rats show different responses in mecamylamine-precipitated nicotine-withdrawal aversion using the conditioned place preference paradigm. Rats were treated subcutaneously with 10 mg/kg/day nicotine for 7 days using an osmotic minipump. After chronic nicotine infusion, the nicotinic receptor antagonist mecamylamine produced a significant place aversion in Lewis, but not in Fischer 344 rats. These results suggest that mecamylamine-precipitated nicotine-withdrawal aversion is strongly regulated by genetic factors. (C) 1999 Elsevier Science B.V. All rights reserved.
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收藏
页码：159 / 162
页数：4
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