Modulation of Notch signaling during somitogenesis

被引:53
作者
Weinmaster, G [1 ]
Kintner, C
机构
[1] Univ Calif Los Angeles, Sch Med, Dept Biol Chem, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Sch Med, Inst Mol Biol, Los Angeles, CA 90095 USA
[3] Salk Inst Biol Studies, San Diego, CA 92186 USA
关键词
somite; segmentation; DSL ligands; lunatic fringe; E3; ligase;
D O I
10.1146/annurev.cellbio.19.111301.115434
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The Notch signaling pathway is known to govern various aspects of tissue differentiation during embryonic development by mediating local cell-cell interactions that often control cell fate. The conserved components that underlie Notch signaling have been isolated in vertebrates, leading to a biochemical delineation of a core Notch signaling pathway and functional studies of this pathway during embryogenesis. Herein we highlight recent progress in determining how Notch signaling contributes to the development of the vertebrate embryo. We first discuss the role of Notch in the process of segmentation where rapid changes have been shown to occur in both the spatial and temporal aspects of Notch signaling, which are critical for segmental patterning. Indeed, the role of Notch in segmentation re-emphasizes a recurring question in Notch biology: How are the components involved in Notch signaling regulated to ensure their dynamic properties? Second, we address this question by discussing recent work on the biochemical mechanisms that potentially regulate Notch signaling during segmentation, including those that act on the receptors, ligands, and signal transduction apparatus.
引用
收藏
页码:367 / 395
页数:31
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