Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis

被引：129

作者：

Khader, Shabaana A. ^{[1
]}

Gopal, Radha ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Pediat, Pittsburgh, PA 15261 USA

来源：

VIRULENCE | 2010年 / 1卷 / 05期

关键词：

IL-17; Th1; Th17; intracellular pathogens; GROWTH-FACTOR-BETA; T-HELPER-CELLS; ENTERICA SEROTYPE TYPHIMURIUM; IL-17; PRODUCTION; DENDRITIC CELLS; MYCOBACTERIAL INFECTION; SEROVAR ENTERITIDIS; INNATE IMMUNITY; TH17; CELLS; ROR-GAMMA;

D O I：

10.4161/viru.1.5.12862

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The identification of a new T-cell subset referred to as T helper 17 (Th17) cells and its role in protective immunity against extracellular bacterial infections is well established. In contrast, initial studies suggested that the IL-23-IL-17 pathway was not required for protection against intracellular pathogens such as mycobacterial infections. However, recent studies demonstrate that Th17-IL-23 pathway may play a crucial role in protective immunity against other intracellular pathogens by regulating the innate and adaptive immune responses. The current outlook on the role of IL-23- IL-17 pathway in protective immunity to intracellular pathogens is discussed here.

引用

页码：423 / 427

页数：5

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