Transgenic mice carrying chimeric or mutated type III intermediate filament (IF) genes

被引：13

作者：

Bloemendal, H ^{[1
]}

Raats, JMH ^{[1
]}

Pieper, FR ^{[1
]}

Benedetti, EL ^{[1
]}

Dunia, I ^{[1
]}

机构：

[1] UNIV PARIS 07,CNRS,INST JACQUES MONOD,DEPT BIOL SUPRAMOL & CELLULAIRE,PARIS,FRANCE

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1997年 / 53卷 / 01期

关键词：

transgenic mice; chimeric IF-genes; cataract;

D O I：

10.1007/PL00000571

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mice carrying chimeric, truncated or mutated genes encoding intermediate filament (IF) proteins type III do not show any detectable severe pathology. However, upon (over)expression of the transgene in the eye lens all animals develop lens opacification (cataract). At the cellular level the loss of visual acuity is preceded by interference with the terminal differentiation of lens fibre cells, plasma membrane damage, distorted assembly of the IF cytoskeleton and perturbation of the cytoskeleton-membrane complex. The degree of expression is paralleled by the extent of the damages.

引用

页码：1 / 12

页数：12

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