Direct measurement of a tethered ligand-receptor interaction potential

被引：220

作者：

Wong, JY ^{[1
]}

Kuhl, TL ^{[1
]}

Israelachvili, JN ^{[1
]}

Mullah, N ^{[1
]}

Zalipsky, S ^{[1
]}

机构：

[1] SEQUUS PHARMACEUT,MENLO PK,CA 94025

来源：

SCIENCE | 1997年 / 275卷 / 5301期

关键词：

D O I：

10.1126/science.275.5301.820

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many biological recognition interactions involve ligands and receptors that are tethered rather than rigidly bound on a cell surface. A surface forces apparatus was used to directly measure the force-distance interaction between a polymer-tethered ligand and its receptor. At separations near the fully extended tether length, the ligands rapidly lock onto their binding sites, pulling the ligand and receptor together. The measured interaction potential and its dynamics can be modeled with standard theories of polymer and colloidal interactions.

引用

页码：820 / 822

页数：3

共 18 条

[1] A NEW STRATEGY FOR ATTACHMENT OF ANTIBODIES TO STERICALLY STABILIZED LIPOSOMES RESULTING IN EFFICIENT TARGETING TO CANCER-CELLS [J].