Minor cytotoxic and antibacterial compounds from the rhizomes of Amomum aculeatum

被引：58

作者：

Heilmann, J ^{[1
]}

Brun, R

Mayr, S

Rali, T

Sticher, O

机构：

[1] ETH Zurich, Inst Pharmaceut Sci, Dept Appl Biosci, CH-8057 Zurich, Switzerland

[2] Swiss Trop Inst, CH-4002 Basel, Switzerland

[3] PNG Biodivers PTY Ltd, Port Moresby, Papua N Guinea

来源：

PHYTOCHEMISTRY | 2001年 / 57卷 / 08期

关键词：

Amomum aculeatum; Zingiberaceae; 1,7-dioxa-dispiro[5.1.5.2]pentadeca-9,12-dien-11-one; aculeatin D; cytotoxicity; antiprotozoal activity;

D O I：

10.1016/S0031-9422(01)00174-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new cytotoxic 1,7-dioxa-dispiro[5.1.5.2]pentadeca-9,2-dien-11-one derivative, aculeatin D, and a new alkenone, 5-hydroxy-hexacos-1-en-3-one, have been isolated as minor compounds from the rhizomes of Amomum aculeatum. Their structures have been determined mainly by NMR spectroscopy and mass spectrometry. Aculeatin D showed high cytotoxicity against the KB and the L-6 cell line with IC50 of 0.38 mug/ml and 1 mug/ml, respectively. Additionally, it revealed remarkable activity against two Plasmodium falciparum strains, as well as against Trypanosoma brucei rhodesiense and Trypanosoma cruzi. 5-Hydroxy-hexacos-1-en-3-one exhibited neither cytotoxic nor antiprotozoal activity, whereas antibacterial testing against Bacillus cereus, Escherichia coli and Staphylococcus epidermidis showed moderate to strong activity for both compounds. (C) 2001 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1281 / 1285

页数：5

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